The “Triple Whammy”: A Drug Combo That Can Harm Your Kidneys
Written by Vic Allen · Owner
ACE inhibitors and diuretics safely control blood pressure — until you add an NSAID. Why this three-drug mix strains your kidneys, and how to pick a safe pain reliever.
Treating high blood pressure has come a long way. We have learned that combination therapy allows us to use lower doses of medication to obtain a positive result, minimizing side effects.
ACE Inhibitors and Diuretics are the most common combo of meds, and are very effective at lowering fluid volume and dilating blood vessels.
Examples of ACE inhibitors are Lisinopril, Losartan, Benazepril, and Enalapril. Examples of diuretics are Hydrochlorothiazide, Furosemide, and Spironolactone.
These combinations safely lower blood pressure, but should not be combined with OTC ibuprofen, naproxen, aspirin, or prescription NSAIDs.
The combination of these three drug classes decrease blood flow through the kidneys and lower fluid volume, hence the term “Triple Whammy.”
We know what happens when vehicles run out of oil: they break down, and that's what can happen to the kidneys with the “Triple Whammy” combination.
Best practice would be to discuss with your pharmacist recommendations for an OTC pain remedy if you are currently taking prescription diuretics and ACE inhibitors.